Category Archives: Uncategorized

2020 Annual Scientific Meeting Award Winners

Congratulations to the Award Winners at the 2020 Annual Scientific Meeting

Scientist in Training Award
Miss Rachel Stapley

INVESTIGATING THE MECHANISMS THROUGH WHICH SLFN14 MUTATIONS CONTRIBUTE TO INHERITED THROMBOCYTOPENIA

Rachel J. Stapley1, Elizabeth J. Haining1, Andrea Bacon2, Steve P. Watson1,3, Neil V. Morgan1
1Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham
2MRC Centre for Immune Regulation, Genome Editing Facility, College of Medical and Dental Sciences, University of Birmingham, UK
3Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, UK

Best Poster Award
Dr Um-May Sumya

DIETARY INTAKE OF ZINC MODULATES PLATELET INTRACELLULAR LEVELS AND HAEMOSTATIC PARAMETERS

U Sumya, J Beattie, F Thies, NJ Mutch
School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD
The Rowett Institute, Foresterhill, Aberdeen, AB25 2ZD

Dr Nicola Mutch and Dr Claire Whyte win funding

The PhD studentship jointly funded by the BSH, Lifeblood and the BSHT has been awarded to Dr Nicola Mutch and Dr Claire Whyte from the University of Aberdeen for the following project:

The impact of thrombus composition on regulation of fibrinolysis under flow

Fibrin structure profoundly impacts a clots susceptibility to fibrinolysis with compact networks linked to early onset of coronary heart disease. Shear stress modulates the structure and cellular composition of thrombi in vivo, but most models of fibrinolysis do not account for flow.  This project will develop a novel flow model which allows thrombus formation and lysis to be visualized in a single system.  Using this novel model and our established Chandler model thrombi system, we will assess how shear rates that mimic venous and arterial circulation affect thrombus structure, composition and susceptibility to lysis. Using fluorescent confocal microscopy we will monitor movement of fibrinolytic proteases through thrombi of different compositions. In turn we will analyse how flow modulates lysis by plasminogen activators and clinically relevant thrombolytic agents.

We wish Nicola and Claire every success with this exciting research project!